Transdermal Drug Delivery, Transdermal Patches

Home Delivery - Transdermal Drug Delivery, Transdermal Patches

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Drug delivery technologies are now receiving necessary concentration from pharmaceutical companies. The main purpose of developing alternative drug delivery technologies is to increase efficiency and safety of drug delivery and contribute more convenience for the patient. Vast explore conducted during the past several years has lead to the improvement of technologies that meet the necessary criteria for delivering the drug straight through a non-invasive route. One of such technologies is transdermal drug delivery.

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Home Delivery

Transdermal drug delivery is the non-invasive delivery of medications from the face of the skin - the largest and most accessible organ of the human body - straight through its layers, to the circulatory system. Medication delivery is carried out by a patch that is attached to the body surface. Transdermal patch is a medicated adhesive pad that is designed to release the active ingredient at a constant rate over a duration of several hours to days after application to the skin. It is also called skin patch. A skin patch uses a extra membrane to control the rate at which the drug contained within the patch can pass straight through the skin and into the bloodstream.

The first transdermal patch was stylish by the Fda in 1979. It was a patch for the rehabilitation of request for retrial sickness. In the mid-1980s, the pharmaceutical associates started the improvement of a nicotine patch to help smokers quit smoking, and within a few months at the end of 1991 and beginning of 1992 the Fda stylish four nicotine patches.

Today drugs administered straight through skin patches include scopolamine (for request for retrial sickness), estrogen (for menopause and to preclude osteoporosis after menopause), nitroglycerin (for angina), lidocaine to comfort the pain of shingles (herpes zoster). Non-medicated patches include thermal and cold patches, weight loss patches, nutrient patches, skin care patches (therapeutic and cosmetic), aroma patches, and patches that measure sunlight exposure.

Advantages and disadvantages of transdermal drug delivery

Transdermal drug delivery systems offer several foremost advantages over more traditional approaches, including:
longer duration of action resulting in a discount in dosing frequency Increased convenience to administer drugs which would otherwise require frequent dosing improved bioavailability more uniform plasma levels reduced side effects and improved therapy due to maintenance of plasma levels up to the end of the dosing interval flexibility of terminating the drug supervision by plainly removing the patch from the skin Improved outpatient compliance and comfort via non-invasive, painless and simple application

Some of the most disadvantages to transdermal drug delivery are:

possibility that a local irritation at the site of application Erythema, itching, and local edema can be caused by the drug, the adhesive, or other excipients in the patch formulation
The main components of a transdermal patch are:

Transdermal patch may include the following components:

Liner - Protects the patch during storage. The liner is removed prior to use. Drug - Drug explication in direct palpate with release liner Adhesive - Serves to adhere the components of the patch together along with adhering the patch to the skin Membrane - Controls the release of the drug from the reservoir and multi-layer patches Backing - Protects the patch from the outer environment
Types of transdermal patches

There are four main types of transdermal patches:

Single-layer Drug-in-Adhesive

In this system the drug is included directly within the skin-contacting adhesive. In this type of patch the adhesive layer is responsible for the releasing of the drug, and serves to adhere the varied layers together, along with the entire system to the skin. The adhesive layer is surrounded by a temporary liner and a backing.

Multi-layer Drug-in-Adhesive

The Multi-layer Drug-in-Adhesive is similar to the Single-layer Drug-in-Adhesive in that the drug is incorporated directly into the adhesive. The multi-layer system adds an additional one layer of drug-in-adhesive, regularly separated by a membrane. This patch also has a temporary liner-layer and a permanent backing.

Reservoir

The reservoir transdermal system develop includes a liquid compartment containing a drug explication or suspension separated from the release liner by a semi-permeable membrane and adhesive. The adhesive component of the goods can whether be as a continuous layer in the middle of the membrane and the release liner or as a concentric configuration around the membrane.

Matrix

The Matrix system has a drug layer of a semisolid matrix containing a drug explication or suspension, which is in direct palpate with the release liner. The adhesive layer in this patch surrounds the drug layer partially overlaying it.

The time to come of transdermal drug delivery

Transdermal drug delivery is theoretically ideal for many injected and orally delivered drugs, but many drugs cannot pass straight through the skin because of skin's low permeability. Pharmaceutical associates develop new adhesives, molecular absorption enhancers, and penetration enhancers that will heighten skin permeability and thus greatly enlarge the range of drugs that can be delivered transdermally.

Two of the better-known technologies that can help accomplish necessary skin permeation enhancement are iontophoresis and phonophoresis (sonophoresis). Iontophoresis involves passing a direct electrical current in the middle of two electrodes on the skin surface. Phonophoresis uses ultrasonic frequencies to help exchange high molecular weight drugs straight through the skin.

A newer and potentially more promising technology is micro needle-enhanced delivery. These systems use an array of tiny needle-like structures to open pores in the stratum corneum and facilitate drug transport. The structures are small enough that they do not reach the nerve endings, so there is no sensation of pain. These systems have been reported to greatly heighten (up to 100,000 fold) the permeation of macromolecules straight through skin.

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